The significance of small animal MRI is far more than just doing the brain and neurological system checks so single. It is a new type of high-tech imaging examination method in recent years. Animal NMR & MRI It is a new medical imaging diagnosis technology applied in human medicine since the 1980s. It has no ionizing radiation (radiation) damage; no bony artifacts; can be multi-directional (transverse, coronal, sagittal, etc.) and multi-parameter imaging; high soft tissue resolution; no need to use contrast agent to display vascular structure And other unique advantages. In general, magnetic resonance imaging (MRI) can be used for almost any part of the animal's body.
Small animal nuclear magnetic resonance function / main application:
Rat, mouse, and dedicated nuclear magnetic resonance imaging system. Used in large and small brain tumors, intracranial hemorrhage, arteriovenous vascular malformations, cerebral ischemia, spinal canal tumors, syringomyelia and hydrocephalus. At the same time on the lumbar intervertebral process, Animal NMR & MRI primary liver cancer and other diseases. Now check the method as follows:
1, T1-weighted images were mainly used in the experimental animal injection of contrast agent, the organization of internal lesions and structure of the imaging. Animal NMR & MRI T1map is used to measure the relaxation time of tissue with compound T1.
2, T2 weighted images were mainly used to observe the size and location of experimental animal lesions. T2map is used to measure the relaxation time of tissue T2.
3, cardiac imaging: used to monitor cardiac cycle activity, observe the heart structure, provide heart function information.
4, angiography (MRA): the use of specialized scanning sequence of experimental animals for three-dimensional raw data acquisition, Animal NMR & MRI into the computer after three-dimensional image fitting reconstruction. The use of professional analysis software can quantitatively analyze the direction of blood flow, flow rate, flow.
5, Diffusion-weighted imaging (DWI): by detecting the proton diffusion movement of the proton around the local magnetic field changes in the signal to obtain the test site DWI and ADC values were analyzed. Mainly used for cerebral ischemia and cerebral infarction, in multiple sclerosis (MS), primary brain tumor and metastatic tumor capsule identification, dementia and other aspects of the relevant research.
6, diffusion tensor imaging (DTI): used to describe the characteristics of water molecules in the diffusion of MRI technology. After the data obtained by computer post-processing can be converted into the average diffusion coefficient, fractional anisotropy, relative anisotropy, Animal NMR & MRI volume ratio and other data. DTI data can be selected by dedicated software to establish a diffusion tracer to describe the direction of the white matter fiber bundle.
7, Perfusion-weighted imaging (PWI), including first-pass dynamic magnetic susceptibility contrast-enhanced resonance perfusion imaging (PWI), arterial hematopoietic marker (ASL) and blood oxygen level-dependent contrast-enhanced imaging (BOLD).
1) Small animal nuclear magnetic resonance imaging of the blood flow through the organization of the blood vessels through the injection of syndromes to the experimental group. The blood flow perfusion status of the tissue was evaluated by measuring some hemodynamic parameters. Cerebral blood volume (CBV), cerebral blood flow (CBF) and mean transit time (MTT) were usually obtained after brain PWI scan. Usually the analysis of parameters used in stroke, brain tumor research and so on.
2) Small animal nuclear magnetic resonance without the introduction of exogenous contrast agent, is a use of blood as an endogenous tracer nuclear magnetic perfusion method. Mainly used in the study of physiological and pathological changes in the physiological state of blood flow.
3) BOLD is based on the level of blood oxygenation dependent effect of small animal nuclear magnetic resonance. BOLD can be used to measure the changes in hemodynamics and metabolic changes in brain activity during brain activity, thus locating the functional area. Can be used to stimulate the experimental animals, Animal NMR & MRI the task conditions to observe which brain area to participate in activities, so as to achieve the purpose of studying brain function.
8, Spectroscopy (MRS): for noninvasive observation of living tissue metabolism and biochemical changes. Study on the Characteristics of Cerebral Metabolism Related to 1H-MRS.
9, ECG and respiratory gated imaging function: can be integrated small animal ECG and respiratory rhythm signals, gated MRI acquisition, the greatest degree of removal of small animal physiological motion on the nuclear signal generated by fuzzy and artifact interference.