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High-tech Applications Of Small Animal NMR
Oct 18, 2017

Small animal nuclear magnetic resonance is a safe, fast, accurate and repeatable living image diagnosis method for animals without injury. For soft tissue imaging has excellent resolution, the nerves, cardiovascular, uterine, joint, muscle, intervertebral disc and spinal cord and other parts of the examination than MICRO-CT, but also in the living organs of the cell or subcellular level of qualitative and quantitative biological process. Animal NMR & MRI A variety of small animal NMR parameters can be used to imaging, multiple imaging parameters to provide a richer diagnostic information, and to adjust the magnetic field to select the desired profile, Animal NMR & MRI can be other imaging techniques can not or difficult to close the site of imaging. The field of small animal nuclear magnetic resonance applications involves materials science, neuroscience, brain function, pharmacology, toxicology, and genetic research.

The small animal NMR uses the static magnetic field and the RF magnetic field to make the human tissue imaging, in the imaging process, Animal NMR & MRI not the electron away from the radiation, also does not need the contrast agent to obtain the high contrast clear picture. It can reflect human organ disorders and early lesions from the inside of human molecules. It is better than x-ray CT in many places.

In addition to the anatomical characteristics of X-ray CT, the small animal MRI can be used to accurately measure the atomic relaxation time T1 and T2, and to reflect the information about the chemical structure in human tissues by NMR principle. This information is reconstructed from the computer by the image of the component (chemical structure image), which has the ability to characterize different tissues of the same density and the different chemical structures of the same tissue through the image display. Animal NMR & MRI This makes it easy to distinguish gray matter from the brain, and the early diagnosis effect of tissue necrosis, malignant disease and degenerative diseases is superior, and the contrast of soft tissue is more accurate. Small Animal MRI (MRI) examination, due to soft tissue synovium, Animal NMR & MRI high resolution of blood vessels, nerves, muscles, tendons, ligaments, and hyaline cartilage for synovial, vascular and muscle, fascia inflammation, synovial cyst and hyaline cartilage degeneration, exfoliation and bone erosion and ischemic necrosis, cervical spine and nucleus pulposus lesions, Clinical examination of knee meniscus and cruciate ligament injury, nerve complication of rheumatoid and osteomyelitis. The macroscopic state of synovial inflammation can be judged, such as the degree and range of fibrin exudation when the synovial volume changes, cell infiltration, angiogenesis and granuloma (Vascular nebula) formation, the early stage of the arthritis of synovial villi and synovial hypertrophy, and its pathological activity. can also distinguish myositis, fascia tension, Animal NMR & MRI fat infiltration and hypertrophy and inflammation of the growth and decline. Can clearly show cervical dislocation, spinal cord compression and spinal cord distortion.

Small animal NMR is a new technology that can be widely used in the fields of materials science and biomedical basic research, and it is very promising in the research of biomedical basic research and disease-related applications. The biomedical research based on animal model can avoid the risk of carrying out experiments in human body, overcome the shortcoming of the long incubation period and long course of disease, and can strictly control animal experiment condition and reduce the influence of individual difference. The method of imaging, especially the small animal nuclear magnetic resonance, is one of the indispensable tools in the research of animal models at present.

Small animal nuclear magnetic resonance acquisition takes fully into account the needs of scientific research and practical applications, which can be applied to the research on the frontier of morphology, Animal NMR & MRI spectroscopy and functional imaging of small animals, and will further enhance the research level and status of research institutes in this field.

Small animal nuclear magnetic resonance is to measure the level of scientific research and research work depth of the symbolic analysis of testing instruments, the beginning of domestic development, is becoming a teaching, scientific research and key disciplines, key laboratory construction indispensable analytical test research means.

According to the current domestic nuclear small animal NMR equipment, the experimental requirements of 1.2T Permanent magnet rats nuclear small animal NMR system, the main technical parameters and experimental functions are as follows:

Main technical parameters

1, magnetic field strength: 1.2t±0.05T;

2, h resonant frequency: 51mhz±2mhz;

3. Magnetic pole diameter: 300mm;

* 4, effective sample diameter (probe coil) Size: Effective sample probe Coil size: φ50mm*h80mm,

* and experimental samples: Experimental Study of whole-space imaging experiment and contrast agent in vivo in vitro in rats

$number, magnetic field uniformity: less than 8ppm (50mmx50mmx80mm)

*7, graphics Resolution: Normal mode 128x128x128 highest resolution 256x256x128,

*, gradient magnetic field strength: 10gs/cm (1mt/cm or 100mt/m)

*9, Absolute Resolution: 0.08mm (with 0.05mm Shume as standard)

10, Image linearity: X, Y, z Three directions are better than 98% (50mmx50mmx80mm)

11, Maximum gradient magnetic field: X, Y, z direction 200mt/m

12, temperature control Stability: cavity temperature control accuracy of ± 0.005 ℃; display accuracy 1m℃.

13, magnetic field Stability: Magnetic field stability per hour Larmor frequency drift less than 100hz/h

14, spatial resolution: Normal mode 0.15mm maximum mode 0.08mm